Monday, 25 August 2014

Solubility Enhancement of Carbamazepine by Using Various Solubility Enhancement Techniques

Solubility Enhancement of Carbamazepine by Using Various Solubility Enhancement Techniques: Carbamazepine, structurally similar to dibenzine derivative is used in the treatment of Epilepsy and pain associated with trigeminal neuralgia. The drug is practically insoluble in water, so the rate of dissolution and bioavailability is less. In this investigation an attempt was made to enhance solubility of carbamazepine by solubility enhancement techniques like Solid dispersion, Inclusion complexation and Crystallization. For solid dispersion phase solubility studies were carried out using Mannitol, PEG 4000 and PVP K 30 and for Inclusion complexation Phase solubility studies were carried out using Complexol-HPTM and HPMC E 3. The solid dispersions, Inclusion complexes and Crystals were prepared by solvent evaporation method and characterized by FT-IR and differential scanning calorimetry (DSC) and evaluated for different parameters. The highest percent cumulative drug release was observed for CBI-2 batch of inclusion complex (97.38% in 60 min.)