Monday, 25 August 2014
Development and Evaluation of Fast Dissolving Tablets of Flurbiprofen
Development and Evaluation of Fast Dissolving Tablets of Flurbiprofen: The aim of the investigation is to prepare the fast dissolving tablet of flurbiprofen. Flurbiprofen, a widely prescribed anti inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor solubility and dissolution rate. The objective of the present study is to develop flurbiprofen fast dissolving tablet formulations by direct compression method by forming its inclusion complex with β-cyclodextrin. The 9 batches were prepared by using super disintegrants. The tablet weight is 350mg.The clathrate is having 1:1 proportion. Inclusion complex of BCD with drug enhance its dissolution and also improve the taste Different super disintegrating agent like cross carmellose sodium, kyron T-314 and SSG in different proportion to enhance solubility of flurbiprofen. The method used was direct compression and directly compressible vehicle used was avicel PH 102, Mannitol was used to fill up the tablet volume and was also acts as sweetener. All the evaluations were performed to check the efficacy and effectiveness of tablet like disintegration time, hardness, friability, wetting time and in-vitro dissolution test. From all the evaluations data batch B6 which contain kyron T-314 as superd isintegrating agent with 15mg in each tablet was evaluated as optimized formula for the preparation of fast dissolving tablet of flurbiprofen.