Monday, 25 August 2014

Development and Characterization of Transdermal Patch for Controlled Release of Fluocinolone Acetonide

Development and Characterization of Transdermal Patch for Controlled Release of Fluocinolone Acetonide: The purpose of this research was to design matrix type of transdermal patch of Fluocinolone acetonide. Polyvinyl pyrrolidone K-30 (PVP K-30) and polyvinyl alcohol (PVA) was used in fixed ratio of 2:5 throughout the study and was concluded from preliminary study. Single layer matrix was chosen for providing 24 hrs. of continuous release. Solvent casting method was used for preparation of patches. 3 level 2 factor full factorial designs was applied for optimization of batch for optimising amount of poly ethylene oxide ( Polyox WSR 1105) and Propylene Glycol (PG). The effects of polymer type, polymer ratio, permeation enhancer, plasticiser on drug release were evaluated by in-vitro release using treated cellophane paper by using Franz diffusion cell. In addition various other characterizations like appearance, folding endurance, tensile strength, % moisture content, % drug content, thickness, flatness was done. ANOVA for Response Surface Quadratic Model for % cumulative drug release and % moisture content responses applied and found significant for optimization. From the contour plot and over lay plot range of various amounts of PG and Polyox found to provide desired responses. Validity of equation was checked by checkpoint batch was true for present work.